Drug Information

Drug General Information
Drug ID
D0C2IE
Former ID
DNC013426
Drug Name
N-(2-phenylpropyl)quinoxaline-2-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528497]
Formula
C18H17N3O
Canonical SMILES
CC(CNC(=O)C1=NC2=CC=CC=C2N=C1)C3=CC=CC=C3
InChI
1S/C18H17N3O/c1-13(14-7-3-2-4-8-14)11-20-18(22)17-12-19-15-9-5-6-10-16(15)21-17/h2-10,12-13H,11H2,1H3,(H,20,22)
InChIKey
UWOAOBCILHACGX-UHFFFAOYSA-N
PubChem Compound ID
22136331
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Inhibitor [528497]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 528497Bioorg Med Chem Lett. 2007 Jan 15;17(2):486-90. Epub 2006 Oct 11.Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.
Ref 528497Bioorg Med Chem Lett. 2007 Jan 15;17(2):486-90. Epub 2006 Oct 11.Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.

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