Drug Information

Drug General Information
Drug ID
D0JV5L
Former ID
DNC006217
Drug Name
4-Methyl-5-(4-piperidyl)isothiazol-3-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528034]
Formula
C9H14N2OS
Canonical SMILES
CC1=C(SNC1=O)C2CCNCC2
InChI
1S/C9H14N2OS/c1-6-8(13-11-9(6)12)7-2-4-10-5-3-7/h7,10H,2-5H2,1H3,(H,11,12)
InChIKey
TVYLWJFICSYNFD-UHFFFAOYSA-N
PubChem Compound ID
11507406
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528034]
Gamma-aminobutyric acid receptor Target Info Inhibitor [528034]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528034]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 528034J Med Chem. 2006 Feb 23;49(4):1388-96.Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.
Ref 528034J Med Chem. 2006 Feb 23;49(4):1388-96.Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.

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