Drug Information

Drug General Information
Drug ID
D04JZJ
Former ID
DNC004824
Drug Name
3-(4-Benzyl-piperidin-1-ylmethyl)-chromen-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527368]
Formula
C22H23NO2
Canonical SMILES
C1CN(CCC1CC2=CC=CC=C2)CC3=COC4=CC=CC=C4C3=O
InChI
1S/C22H23NO2/c24-22-19(16-25-21-9-5-4-8-20(21)22)15-23-12-10-18(11-13-23)14-17-6-2-1-3-7-17/h1-9,16,18H,10-15H2
InChIKey
WZWRAAKVOATXPL-UHFFFAOYSA-N
PubChem Compound ID
2838196
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [527368]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 527368J Med Chem. 2005 Jan 13;48(1):266-73.Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.
Ref 527368J Med Chem. 2005 Jan 13;48(1):266-73.Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.

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