Drug Information

Drug General Information
Drug ID
D07WQV
Former ID
DIB018785
Drug Name
AH23848
Synonyms
(-)AH23848; AH23848; (-)-AH23848; AH 23848; AH-23848
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539248]
Formula
C29H35NO5
InChI
InChI=1S/C29H35NO5/c31-26-20-27(35-21-22-12-14-24(15-13-22)23-8-4-3-5-9-23)25(10-6-1-2-7-11-28(32)33)29(26)30-16-18-34-19-17-30/h1-5,8-9,12-15,25,27,29H,6-7,10-11,16-21H2,(H,32,33)/b2-1-/t25-,27-,29+/m0/s1
InChIKey
IOFUFYLETVNNRF-OSAZKUMMSA-N
PubChem Compound ID
5310999
PubChem Substance ID
7978653, 11056198, 12013495, 14883326, 39340732, 79808410, 114155016, 135649908, 229499889
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Antagonist [525673]
Prostaglandin E2 receptor, EP4 subtype Target Info Antagonist [534595]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activationhsa04080:Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptorR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Vitamin D Receptor Pathway
GPCR downstream signaling
References
Ref 539248(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1949).
Ref 525673The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.
Ref 534595Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41.

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