Drug Information

Drug General Information
Drug ID
D04UDE
Former ID
DNC013307
Drug Name
7-(4,6-dimethoxypyrimidin-2-yl)-2-methylquinoline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528793]
Formula
C16H15N3O2
Canonical SMILES
CC1=NC2=C(C=C1)C=CC(=C2)C3=NC(=CC(=N3)OC)OC
InChI
1S/C16H15N3O2/c1-10-4-5-11-6-7-12(8-13(11)17-10)16-18-14(20-2)9-15(19-16)21-3/h4-9H,1-3H3
InChIKey
BWVPGOLPFZULHO-UHFFFAOYSA-N
PubChem Compound ID
44427383
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528793]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528793Bioorg Med Chem Lett. 2007 Jun 1;17(11):2987-91. Epub 2007 Mar 24.Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists.
Ref 528793Bioorg Med Chem Lett. 2007 Jun 1;17(11):2987-91. Epub 2007 Mar 24.Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists.

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