Drug Information

Drug General Information
Drug ID
D09GMG
Former ID
DNC013057
Drug Name
3-methoxy-N-(6-methylpyridin-2-yl)benzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528186]
Formula
C14H14N2O2
Canonical SMILES
CC1=NC(=CC=C1)NC(=O)C2=CC(=CC=C2)OC
InChI
1S/C14H14N2O2/c1-10-5-3-8-13(15-10)16-14(17)11-6-4-7-12(9-11)18-2/h3-9H,1-2H3,(H,15,16,17)
InChIKey
RGDXTZSZZQXINX-UHFFFAOYSA-N
PubChem Compound ID
585532
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528186]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528186Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. Epub 2006 May 5.Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.
Ref 528186Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. Epub 2006 May 5.Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.

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