Drug Information

Drug General Information
Drug ID
D0Y1MW
Former ID
DNC000558
Drug Name
Difluoromethylornithine
Drug Type
Small molecular drug
Indication Trypanosoma brucei gambiense infection [ICD9: 86.5; ICD10:B56] Phase 2 [523970]
Formula
C6H13F2N2O2+
Canonical SMILES
C(CC(C(F)F)(C(=O)[O-])[NH3+])C[NH3+]
InChI
1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)/p+1
InChIKey
VLCYCQAOQCDTCN-UHFFFAOYSA-O
CAS Number
CAS 67037-37-0
PubChem Compound ID
25202558
PubChem Substance ID
57392814
ChEBI ID
ChEBI:41948
SuperDrug ATC ID
P01CX03
SuperDrug CAS ID
cas=070052129
Target and Pathway
Target(s) Ornithine decarboxylase Target Info Inhibitor [537878]
Arginase II, mitochondrial Target Info Inhibitor [535841]
BioCyc Pathway Putrescine biosynthesis I
KEGG Pathway Arginine and proline metabolism
Metabolic pathways
Biosynthesis of antibiotics
Biosynthesis of amino acids
Amoebiasis
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Ornithine degradation
CCKR signaling map ST
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
PathWhiz Pathway Spermidine and Spermine Biosynthesis
WikiPathways Urea cycle and metabolism of amino groups
Metabolism of amino acids and derivatives
References
Ref 523970ClinicalTrials.gov (NCT01636128) Urinary Biomarker Study With Sulindac and Difluoromethylornithine. U.S. National Institutes of Health.
Ref 535841Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation. 2003 Oct 21;108(16):2000-6. Epub 2003 Sep 29.
Ref 537878An inhibitor of polyamine biosynthesis impairs human polymorphonuclear leukocyte priming by tumor necrosis factor alpha. J Leukoc Biol. 1995 Feb;57(2):282-6.

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