Drug Information

Drug General Information
Drug ID
D00QVP
Former ID
DNC013035
Drug Name
6,11-dihydrothiochromeno[4,3-b]indol-8-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528123]
Formula
C15H11NOS
Canonical SMILES
C1C2=C(C3=CC=CC=C3S1)NC4=C2C=C(C=C4)O
InChI
1S/C15H11NOS/c17-9-5-6-13-11(7-9)12-8-18-14-4-2-1-3-10(14)15(12)16-13/h1-7,16-17H,8H2
InChIKey
BVGUKMAMOJMOFD-UHFFFAOYSA-N
PubChem Compound ID
44411868
Target and Pathway
Target(s) Androgen receptor Target Info Inhibitor [528123]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 528123Bioorg Med Chem Lett. 2006 Jun 15;16(12):3233-7. Epub 2006 Apr 5.Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands.
Ref 528123Bioorg Med Chem Lett. 2006 Jun 15;16(12):3233-7. Epub 2006 Apr 5.Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands.

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