TTD | Drug: D09XAM

Drug General Information
Drug ID	D09XAM
Former ID	DIB018867
Drug Name	APR19
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[543233]
Formula	C21H32F2
InChI	InChI=1S/C21H32F2/c1-13-4-7-17-16-6-5-14-12-15(22)8-10-20(14,2)18(16)9-11-21(17,3)19(13)23/h5,13,15-19H,4,6-12H2,1-3H3/t13-,15+,16?,17?,18?,19+,20+,21+/m1/s1
InChIKey	UEILQXVVJHZGQK-KYFJQHFKSA-N
PubChem Compound ID	54596718
PubChem Substance ID	131405395, 237280766, 252166862
Target and Pathway
Target(s)	Progesterone receptor	Target Info	Antagonist	[532304]
KEGG Pathway	Oocyte meiosis
KEGG Pathway	Progesterone-mediated oocyte maturation
Pathway Interaction Database	Cellular roles of Anthrax toxin
Reactome	Nuclear signaling by ERBB4
Reactome	Nuclear Receptor transcription pathway
WikiPathways	Ovarian Infertility Genes
	Signaling by ERBB4
	Nuclear Receptors
References
Ref 543233	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8662).
Ref 532304	A new strategy for selective targeting of progesterone receptor with passive antagonists. Mol Endocrinol. 2013 Jun;27(6):909-24.

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Drug Information