Drug Information

Drug General Information
Drug ID
D04LDP
Former ID
DNC000081
Drug Name
5-deoxy-5-phosphono-D-arabinonate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535707]
Formula
C5H8O8P-3
Canonical SMILES
C(C(C(C(C(=O)[O-])O)O)O)P(=O)([O-])[O-]
InChI
1S/C5H11O8P/c6-2(1-14(11,12)13)3(7)4(8)5(9)10/h2-4,6-8H,1H2,(H,9,10)(H2,11,12,13)/p-3
InChIKey
XCBNBIPHASXSKG-UHFFFAOYSA-K
PubChem Compound ID
56603745
PubChem Substance ID
134339615
Target and Pathway
Target(s) 6-phosphogluconate dehydrogenase, decarboxylating Target Info Inhibitor [535707]
BioCyc Pathway Pentose phosphate pathway
Pentose phosphate pathway (oxidative branch)
KEGG Pathway Pentose phosphate pathway
Glutathione metabolism
Metabolic pathways
Biosynthesis of antibiotics
Carbon metabolism
PANTHER Pathway Pentose phosphate pathway
PathWhiz Pathway Warburg Effect
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Metabolism of carbohydrates
Pentose Phosphate Pathway
References
Ref 535707Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei. Bioorg Med Chem. 2003 Apr 3;11(7):1207-14.
Ref 535707Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei. Bioorg Med Chem. 2003 Apr 3;11(7):1207-14.

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