Drug Information

Drug General Information
Drug ID
D07GTB
Former ID
DNC008924
Drug Name
L-660771
Synonyms
MK-571
Drug Type
Small molecular drug
Indication Discovery agent Discontinued in Phase 2 [541365], [544533]
Formula
C26H27ClN2O3S2
InChI
InChI=1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+/t26-/m1/s1
InChIKey
AXUZQJFHDNNPFG-LHAVAQOQSA-N
PubChem Compound ID
6509849
PubChem Substance ID
7849443, 11624344, 14811473, 43170034, 50998907, 57370844, 103177757, 103925954, 114611256, 135018129, 137264022, 152258915, 160647761, 164235357, 164766111, 172919830, 178102814, 185990401, 198962625, 198966715, 223554776, 226423091, 252481554
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 541365(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6193).
Ref 544533Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000074)

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