Drug Information

Drug General Information
Drug ID
D02QJW
Former ID
DIB019152
Drug Name
clofilium
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539629]
Formula
C21H37ClN+
InChI
InChI=1S/C21H37ClN/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20/h14-17H,4-13,18-19H2,1-3H3/q+1
InChIKey
WPSYTTKBGAZSCX-UHFFFAOYSA-N
PubChem Compound ID
2798
PubChem Substance ID
854018, 4302950, 7980451, 8151807, 11467467, 11486273, 29221953, 47216986, 47515532, 47589186, 47589187, 49698434, 50070299, 50070958, 50113156, 50113157, 50315463, 53801073, 57321467, 92098481, 103168791, 104040003, 104301643, 126407453, 129616320, 131333045, 135065239, 137231979, 141640747, 142611651, 162220962, 162633875, 179150928, 198985509, 223442442, 226521405, 244578489, 252661029
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily A member 5 Target Info Blocker (channel blocker) [533766]
Kv10.1 Target Info Blocker (channel blocker) [526508]
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways Potassium Channels
References
Ref 539629(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2507).
Ref 526508Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. Br J Pharmacol. 2003 Jan;138(1):161-71.
Ref 533766Mechanism of clofilium block of the human Kv1.5 delayed rectifier potassium channel. Mol Pharmacol. 1995 Jan;47(1):198-205.

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