Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T63083
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| Former ID |
TTDR00922
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| Target Name |
DNA repair protein RAD51 homolog 1
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| Gene Name |
RAD51
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| Synonyms |
HRAD51; HsRAD51; RAD51
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| Target Type |
Research
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| Function |
Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2- scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role inDNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.
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| BioChemical Class |
DNA repair
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| UniProt ID | |||||
| Sequence |
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKEL
INIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETG SITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGL SGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSA RQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRL YLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD |
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| Pathways | |||||
| KEGG Pathway | Homologous recombination | ||||
| Fanconi anemia pathway | |||||
| Pathways in cancer | |||||
| Pancreatic cancer | |||||
| Pathway Interaction Database | p73 transcription factor network | ||||
| ATR signaling pathway | |||||
| BARD1 signaling events | |||||
| Reactome | HDR through Single Strand Annealing (SSA) | ||||
| HDR through Homologous Recombination (HRR) | |||||
| Presynaptic phase of homologous DNA pairing and strand exchange | |||||
| Meiotic recombination | |||||
| WikiPathways | DNA Damage Response | ||||
| Meiotic Recombination | |||||
| ATM Signaling Pathway | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Integrated Breast Cancer Pathway | |||||
| Homologous recombination | |||||
| Double-Strand Break Repair | |||||
| miRNA Regulation of DNA Damage Response | |||||
| References | |||||
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