Target Information

Target General Infomation
Target ID
T81015
Former ID
TTDR01089
Target Name
Orotidine 5'-phosphate decarboxylase
Gene Name
pyrF
Synonyms
OMP decarboxylase; OMPDCase; OMPdecase; pyrF
Target Type
Research
BioChemical Class
Carbon-carbon lyase
Target Validation
T81015
UniProt ID
P9WIU2
EC Number
EC 4.1.1.23
Sequence
MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFCDICVRAFADFAVVKP
QVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGATMSAYATAWVGDSPLAADA
VTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQNAAADGRSVAQLVVDQVGA
ANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQGGRPEALGGLGGAASSQLL
PAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV
Inhibitor 6-amino-uridine monophosphate Drug Info [528351]
6-aza-uridine monophosphate Drug Info [528351]
6-Hydroxyuridine-5'-Phosphate Drug Info [551393]
Uridine-5'-Monophosphate Drug Info [551393]
Xanthosine-5'-monophosphate disodium salt Drug Info [529249]
References
Ref 528351J Med Chem. 2006 Aug 10;49(16):4937-45.Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics.
Ref 529249J Med Chem. 2008 Feb 14;51(3):432-8. Epub 2008 Jan 9.Structural diversity and plasticity associated with nucleotides targeting orotidine monophosphate decarboxylase.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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