Target Information

Target General Infomation
Target ID
T76497
Former ID
TTDR00910
Target Name
6-phosphogluconate dehydrogenase, decarboxylating
Gene Name
PGD
Synonyms
6-phosphogluconate dehydrogenase; 6PGDH; PGD
Target Type
Research
Function
Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
BioChemical Class
Short-chain dehydrogenases reductases
Target Validation
T76497
UniProt ID
P52209
EC Number
EC 1.1.1.44
Sequence
MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKE
MVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKG
ILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAG
HFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANIL
KFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQA
SKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIAL
MWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPM
PCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSS
YNA
Inhibitor (2R)-2-Methyl-4,5-dideoxy Drug Info [535749]
(2R)-2-methyl-4-deoxy and 2,4-dideoxy Drug Info [535749]
4-phospho-D-erythronate Drug Info [551221]
5-deoxy-5-phosphono-D-arabinonate Drug Info [535707]
6-Phosphogluconic Acid Drug Info [551393]
Pyrophosphate 2- Drug Info [551374]
Pathways
BioCyc Pathway Pentose phosphate pathway
Pentose phosphate pathway (oxidative branch)
KEGG Pathway Pentose phosphate pathway
Glutathione metabolism
Metabolic pathways
Biosynthesis of antibiotics
Carbon metabolism
PANTHER Pathway Pentose phosphate pathway
PathWhiz Pathway Warburg Effect
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Metabolism of carbohydrates
Pentose Phosphate Pathway
References
Ref 535707Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei. Bioorg Med Chem. 2003 Apr 3;11(7):1207-14.
Ref 535749Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14.
Ref 551221Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorg Med Chem. 2010 Jul 15;18(14):5056-62. doi: 10.1016/j.bmc.2010.05.077. Epub 2010 Jun 9.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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