Target Information

Target General Infomation
Target ID
T04741
Former ID
TTDR00945
Target Name
Phosphoribosylaminoimidazolecarboxamide formyltransferase
Gene Name
ATIC
Synonyms
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase; AICARFT; ATIC
Target Type
Research
Disease Cancer [ICD9: 140-229; ICD10: C00-C96]
BioChemical Class
Methyltransferase superfamily
Target Validation
T04741
UniProt ID
P31939
EC Number
EC 2.1.2.3
Sequence
MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEM
LGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEA
VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFT
HTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINL
CDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPIS
AAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNG
NYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIV
ATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKT
GVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDA
FFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH
Inhibitor FAICAR Drug Info [528699]
NSC-126445 Drug Info [527350]
NSC-26699 Drug Info [527350]
NSC-292213 Drug Info [527350]
NSC-30171 Drug Info [527350]
NSC-324572 Drug Info [527350]
NSC-37031 Drug Info [527350]
NSC-37173 Drug Info [527350]
NSC-45592 Drug Info [527350]
NSC-47729 Drug Info [527350]
NSC-58046 Drug Info [527350]
NSC-88915 Drug Info [527350]
References
Ref 527350J Med Chem. 2004 Dec 30;47(27):6681-90.Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors.
Ref 528699J Biol Chem. 2007 Apr 27;282(17):13033-46. Epub 2007 Feb 26.Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.