Target Information

Target General Infomation
Target ID
T88126
Former ID
TTDR00348
Target Name
Nicotinate-nucleotide adenylyltransferase
Gene Name
nadD
Synonyms
Deamido-NAD(+) diphosphorylase; Deamido-NAD(+) pyrophosphorylase; Deamido-NAD(+)Nicotinate-nucleotide adenylyltransferase pyrophosphorylase; NaMN adenylyltransferase; Nicotinate mononucleotide adenylyltransferase; nadD
Target Type
Research
Function
Catalyzes the reversible adenylation of nicotinate mononucleotide (namn) to nicotinic acid adenine dinucleotide (naad).
BioChemical Class
Kinase
UniProt ID
P0A752
EC Number
EC 2.7.7.18
Sequence
MKSLQALFGGTFDPVHYGHLKPVETLANLIGLTRVTIIPNNVPPHRPQPEANSVQRKHML
ELAIADKPLFTLDERELKRNAPSYTAQTLKEWRQEQGPDVPLAFIIGQDSLLTFPTWYEY
ETILDNAHLIVCRRPGYPLEMAQPQYQQWLEDHLTHNPEDLHLQPAGKIYLAETPWFNIS
ATIIRERLQNGESCEDLLPEPVLTYINQQGLYR
Binder Deamido-NAD Drug Info [535348]
Inhibitor Deamido-Nad+ Drug Info [551393]
Nicotinamide-Adenine-Dinucleotide Drug Info [551393]
References
Ref 535348Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD. Structure. 2002 Jan;10(1):69-79.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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