Target Information

Target General Infomation
Target ID
T59445
Former ID
TTDR00879
Target Name
Sorbitoldehydrogenase
Gene Name
SORD
Synonyms
L-iditol2-dehydrogenase; SDH; SORD
Target Type
Research
Function
Convertssorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.
BioChemical Class
Short-chain dehydrogenases reductases
UniProt ID
Q00796
EC Number
EC 1.1.1.14
Sequence
MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNF
IVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFC
ATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCG
AGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQL
GCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRY
CNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
Inhibitor CP-470,711 Drug Info [535844]
Nicotinamide-Adenine-Dinucleotide Drug Info [551393]
Pathways
BioCyc Pathway Sorbitol degradation I
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Metabolic pathways
NetPath Pathway TSH Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
WikiPathways Polyol Pathway
References
Ref 535844Sorbitol dehydrogenase: a novel target for adjunctive protection of ischemic myocardium. FASEB J. 2003 Dec;17(15):2331-3. Epub 2003 Oct 2.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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