Target Information

Target General Infomation
Target ID
T42854
Former ID
TTDI02338
Target Name
Melanoma associated antigen 1
Gene Name
MAGEA1
Synonyms
Antigen MZ2E; CT1.1; Cancer/testis antigen 1.1; MAGE1 antigen; Melanomaassociated antigen 1; MAGEA1
Target Type
Discontinued
Disease Melanoma [ICD9: 172; ICD10: C43]
Function
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
BioChemical Class
Melanoma associated antigen family
UniProt ID
P43355
Sequence
MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLEEVPTAGSTDPPQSPQG
ASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVITKKVADLVGFLLLKYRAR
EPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVKEADPTGHSYVLVTCLGLSYD
GLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEELSVMEVYDGREHSAYGEPRKLLT
QDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSYVKVLEYVIKVSARVRFFFPSLREA
ALREEEEGV
Drugs and Mode of Action
Drug(s) Melanoma vaccine Drug Info Discontinued in Phase 2 Melanoma [547218]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
WikiPathways Notch Signaling Pathway
References
Ref 547218Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014153)
Ref 531162Preclinical qualification of a new multi-antigen candidate vaccine for metastatic melanoma. J Immunother. 2010 Oct;33(8):743-58.

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