Target Information

Target General Infomation
Target ID
T11253
Former ID
TTDC00269
Target Name
mRNA of Heatshock 27 kDa protein
Gene Name
HSPB1
Synonyms
28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; HSP 27; Heat shock protein 27; HspB1; SRP27; Stress-responsive protein 27; HSPB1
Target Type
Discontinued
Disease Arthritis [ICD9: 710-719; ICD10: M00-M25]
Breast cancer; Ovarian cancer; Bladder cancer; Prostate cancer; Lung cancer [ICD9: 140-229, 162, 183, 188; ICD10: C00-C96, C33-C34, C56, C67]
Function
Involved in stress resistance and actin organization.
BioChemical Class
Heat shock protein
Target Validation
T11253
UniProt ID
P04792
Sequence
MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPLPP
AAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEI
TGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEIT
IPVTFESRAQLGGPEAAKSDETAAK
Drugs and Mode of Action
Drug(s) SB-242235 Drug Info Discontinued in Phase 1 Arthritis [546871]
Inhibitor SB-242235 Drug Info [529583]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway MAPK signaling pathway
VEGF signaling pathway
Amoebiasis
Epstein-Barr virus infection
NetPath Pathway EGFR1 Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
p38 MAPK pathway
CCKR signaling map ST
Pathway Interaction Database p38 signaling mediated by MAPKAP kinases
Signaling mediated by p38-alpha and p38-beta
Reactome VEGFA-VEGFR2 Pathway
MAPK6/MAPK4 signaling
WikiPathways p38 MAPK Signaling Pathway
MAPK Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Apoptosis-related network due to altered Notch3 in ovarian cancer
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
References
Ref 546871Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010787)
Ref 529583Bioorg Med Chem Lett. 2008 Aug 1;18(15):4433-7. Epub 2008 Jun 12.Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.
Ref 551023Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.

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