Target Information

Target General Infomation
Target ID
T64682
Former ID
TTDR01250
Target Name
Serine/threonine-protein kinase Sgk1
Gene Name
SGK1
Synonyms
Serum/glucocorticoid-regulated kinase 1; SGK1
Target Type
Clinical Trial
Disease Prostate cancer [ICD9: 185; ICD10: C61]
BioChemical Class
Kinase
Target Validation
T64682
UniProt ID
O00141
EC Number
EC 2.7.11.1
Sequence
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
Structure
2R5T; 3HDM; 3HDN
Drugs and Mode of Action
Drug(s) CI-1040 Drug Info Phase 2 Discovery agent [521505], [541019]
Inhibitor 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole Drug Info [527308]
CGP-57380 Drug Info [529039]
CI-1040 Drug Info [525872]
GF-109203 Drug Info [525872]
GSK-650394 Drug Info [542938]
KN-62 Drug Info [525872]
RO-316233 Drug Info [525872]
Pathways
KEGG Pathway FoxO signaling pathway
PI3K-Akt signaling pathway
Aldosterone-regulated sodium reabsorption
NetPath Pathway IL5 Signaling Pathway
FSH Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Insulin Pathway
Glucocorticoid receptor regulatory network
mTOR signaling pathway
FoxO family signaling
Class I PI3K signaling events
Reactome Stimuli-sensing channels
WikiPathways Insulin Signaling
Iron uptake and transport
FSH signaling pathway
References
Ref 521505ClinicalTrials.gov (NCT00033384) CI-1040 in Treating Patients With Advanced Breast, Colon, Pancreatic, or Non-Small Cell Lung Cancer. U.S. National Institutes of Health.
Ref 541019(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5676).
Ref 525872Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Ref 527308J Med Chem. 2004 Dec 2;47(25):6239-47.Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
Ref 529039Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update.
Ref 542938(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8040).

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