Target Information

Target General Infomation
Target ID
T35445
Former ID
TTDR00819
Target Name
Mothers against decapentaplegic homolog 3
Gene Name
SMAD3
Synonyms
HMAD-3; HSMAD3; JV15-2; MMad3; Mad3; Mothers against DPP homolog 3; SMAD 3; Smad3; TGF-beta response effector Smad3; SMAD3
Target Type
Successful
Disease Ocular disease [ICD10: H00-H59]
Function
Transcriptional modulator activated by tgf-beta (transforming growth factor) and activin type 1 receptor kinase. Smad3 is a receptor-regulated smad (r-smad). In mouse required for establishemnt of the mucosal immune response.
Target Validation
T35445
UniProt ID
P84022
Sequence
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNV
NTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEV
CVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP
PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYEL
NQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG
GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF
EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR
CSSVS
Drugs and Mode of Action
Drug(s) FLUORESCEIN Drug Info Approved Ocular disease [551871]
Inhibitor ELLAGIC ACID Drug Info [531262]
FLUORESCEIN Drug Info [531262]
GNF-PF-2272 Drug Info [531262]
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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