Resistance mutation info of target

Target General Information
Target ID T94085
Target Name Retinoic acid receptor alpha (RARA) Target Info
Gene Name RARA
Species Homo sapiens
Uniprot ID RARA_HUMAN
Sequence MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP [Homo sapiens]
Drug Resistance Mutation and Corresponding Drugs
Ref 538332FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 078729.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Mutation Info Missense: A216V
Drugs
Drug Name Arsenic trioxide Drug Info [1559242]
Targeted Disease Promyelocytic leukemia
Reference
Ref 1559242Evaluating frequency of PML-RARA mutations and conferring resistance to arsenic trioxide-based therapy in relapsed acute promyelocytic leukemia patients.Ann Hematol.2015 Nov;94(11):1829-37.

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