Drug Information

Drug General Information
Drug ID
D0ZI0C
Former ID
DIB007781
Drug Name
Dersalazine
Synonyms
UR-12715; UR-12746
Drug Type
Small molecular drug
Indication Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] Phase 2 [544223]
Company
Grupo Uriach
Formula
C35H31N6NaO4
Canonical SMILES
n1(c(nc2c1ccnc2)C)CC1CCN(C(=O)/C=C(\c2ccc(/N=N/c3cc(C(=<br />O)O)c(cc3)O)cc2)/c2ccccc2)CC1
CAS Number
CAS 188913-58-8
PubChem Compound ID
57331752
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Inhibitor [544223]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 544223The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis. Br J Pharmacol. 2012 February; 165(3): 729-740.
Ref 544223The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis. Br J Pharmacol. 2012 February; 165(3): 729-740.

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