Drug Information

Drug General Information
Drug ID
D0Z7LS
Former ID
DNC010137
Drug Name
3,3-Diethyl-1-o-tolylazetidine-2,4-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530511]
Formula
C14H17NO2
Canonical SMILES
CCC1(C(=O)N(C1=O)C2=CC=CC=C2C)CC
InChI
1S/C14H17NO2/c1-4-14(5-2)12(16)15(13(14)17)11-9-7-6-8-10(11)3/h6-9H,4-5H2,1-3H3
InChIKey
QNAKQLGCEYBHNC-UHFFFAOYSA-N
PubChem Compound ID
44626810
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [530511]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 530511J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.
Ref 530511J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

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