Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Z7CZ
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| Former ID |
DIB020198
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| Drug Name |
L-CCG-I
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| Synonyms |
3,4-Cyclopropylglutamate; CCPG; L-2-(Carboxypropyl)glycine; L-CCG-I
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [538846] | ||
| Formula |
C6H9NO4
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| InChI |
InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3-,4-/m0/s1
|
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| InChIKey |
GZOVEPYOCJWRFC-HZLVTQRSSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Metabotropic glutamate receptor 8 | Target Info | Agonist | [525476] | |
| Metabotropic glutamate receptor 2 | Target Info | Agonist | [525619] | ||
| Metabotropic glutamate receptor3 | Target Info | Agonist | [525619] | ||
| Metabotropic glutamate receptor 7 | Target Info | Agonist | [525945] | ||
| Metabotropicglutamate receptor 1 | Target Info | Agonist | [525911] | ||
| Metabotropic glutamate receptor 5 | Target Info | Agonist | [525911] | ||
| Metabotropic glutamate receptor 4 | Target Info | Agonist | [526752] | ||
| mGlu6 receptor | Target Info | Agonist | [534761] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Glutamatergic synapsehsa04080:Neuroactive ligand-receptor interaction | |||||
| Glutamatergic synapse | |||||
| Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction | |||||
| Glutamatergic synapsehsa04020:Calcium signaling pathway | |||||
| FoxO signaling pathway | |||||
| Gap junction | |||||
| Long-term potentiation | |||||
| Retrograde endocannabinoid signaling | |||||
| Long-term depression | |||||
| Estrogen signaling pathwayhsa04020:Calcium signaling pathway | |||||
| Huntington's diseasehsa04080:Neuroactive ligand-receptor interaction | |||||
| Taste transduction | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Ionotropic glutamate receptor pathway | |||||
| Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathway | |||||
| Metabotropic glutamate receptor group I pathway | |||||
| Endogenous cannabinoid signalingP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Endogenous cannabinoid signalingP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP501:GPCRs, Class C Metabotropic glutamate, pheromone | |||||
| GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone | |||||
| GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCRs, OtherWP666:Hypothetical Network for Drug Addiction | |||||
| References | |||||
| Ref 525476 | Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10. | ||||
| Ref 525619 | [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology. 1999 Oct;38(10):1519-29. | ||||
| Ref 525911 | Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. | ||||
| Ref 525945 | Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. | ||||
| Ref 526752 | Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br J Pharmacol. 1992 Oct;107(2):539-43. | ||||
| Ref 534761 | Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology. 1998 Aug;37(8):1043-51. | ||||
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