Drug Information

Drug General Information
Drug ID
D0Z6DG
Former ID
DIB021010
Drug Name
T13
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542014]
Formula
C23H42NaO6PS
InChI
InChI=1S/C23H43O6PS.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(24)28-22-20-27-19-18-21(22)29-30(25,26)31;/h9-10,21-22H,2-8,11-20H2,1H3,(H2,25,26,31);/q;+1/p-1/b10-9-;/t21-,22+;/m0./s1
InChIKey
DFEVXZSENXLXQQ-LYOQJJATSA-M
PubChem Compound ID
73755252
PubChem Substance ID
178103563
Target and Pathway
Target(s) Lysophosphatidate-3 receptor Target Info Agonist [529681]
Lysophosphatidic acid receptor Edg-2 Target Info Agonist [531119]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Pathways in cancerhsa04015:Rap1 signaling pathway
Gap junction
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database LPA receptor mediated eventslysophospholipid_pathway:LPA receptor mediated events
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Lysosphingolipid and LPA receptorsR-HSA-416476:G alpha (q) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP289:Myometrial Relaxation and Contraction Pathways
Small Ligand GPCRs
GPCR downstream signaling
References
Ref 542014(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6984).
Ref 529681LPA and its analogs-attractive tools for elucidation of LPA biology and drug development. Curr Med Chem. 2008;15(21):2122-31.
Ref 531119Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors. Acta Pharmacol Sin. 2010 Sep;31(9):1213-22.

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