Drug Information

Drug General Information
Drug ID
D0Z5AC
Former ID
DIB000960
Drug Name
Gonadimmune
Synonyms
GnRH pharmaccine, Aphton/GlaxoSmithKline
Indication Prostate cancer [ICD9: 185; ICD10:C61] Discontinued in Phase 2 [546282]
Company
Aphton
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Modulator [526646]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 546282Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007230)
Ref 526646A novel retro-inverso gonadotropin-releasing hormone (GnRH) immunogen elicits antibodies that neutralize the activity of native GnRH. Endocrinology. 2003 Jul;144(7):3262-9.

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