Drug Information

Drug General Information
Drug ID
D0Z3UP
Former ID
DIB000380
Drug Name
Dabuzalgron
Synonyms
R-450; Alpha-1 adrenoceptor agonist, Roche; Ro-115-1240
Drug Type
Small molecular drug
Indication Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32] Discontinued in Phase 2 [540407], [547205]
Company
Roche
Formula
C12H16ClN3O3S
InChI
InChI=1S/C12H16ClN3O3S/c1-8-10(19-7-11-14-5-6-15-11)4-3-9(13)12(8)16-20(2,17)18/h3-4,16H,5-7H2,1-2H3,(H,14,15)
InChIKey
FOYWMEJSRSBQGB-UHFFFAOYSA-N
CAS Number
CAS 219311-44-1
PubChem Compound ID
216249
PubChem Substance ID
9372818, 14923699, 30419991, 74887168, 103564401, 103838444, 113461218, 117632348, 125824103, 126680976, 127878658, 135135692, 135589238, 137263567, 160856481, 162153033, 178100463, 179150165, 198976064, 219812649, 223664499, 231057545, 241053107, 249626435, 252125388, 252765853
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Agonist [540407]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540407(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3469).
Ref 547205Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013967)
Ref 540407(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3469).

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