Drug Information

Drug General Information
Drug ID
D0Z3NE
Former ID
DIB019552
Drug Name
compound 5i
Synonyms
GNF-PF-3777
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532500]
Formula
C15H7N3O4
InChI
InChI=1S/C15H7N3O4/c19-13-10-7-8(18(21)22)5-6-12(10)17-14(13)16-11-4-2-1-3-9(11)15(17)20/h1-7H
InChIKey
UFMQJYHLIUACCG-UHFFFAOYSA-N
PubChem Compound ID
478573
PubChem Substance ID
636352, 10308756, 14849249, 38929871, 47414899, 47453611, 51715820, 103274195, 109724735, 129360987, 131334995, 143367779, 163217091, 179333246, 194940887, 224989445, 230501187, 249565903
Target and Pathway
Target(s) Indoleamine 2,3-dioxygenase Target Info Inhibitor [532500]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation
L-kynurenine degradation
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
NAD de novo biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
African trypanosomiasis
NetPath Pathway TSLP Signaling Pathway
IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Tryptophan Metabolism
Reactome Tryptophan catabolism
WikiPathways Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 532500Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem. 2013 Nov 14;56(21):8321-31.
Ref 532500Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem. 2013 Nov 14;56(21):8321-31.

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