Drug Information

Drug General Information
Drug ID
D0Z0EH
Former ID
DIB009038
Drug Name
PheTQS
Synonyms
PheTQS; Alpha7 nicotinic acetylcholine receptor positive allosteric modulators (PAMs) (CNS disorders), GlaxoSmithKline; Alpha7 nicotinic acetylcholine receptor positive allosteric modulators (PAMs) (CNS disorders), Proximagen
Indication Central nervous system disease [ICD10:G00-G99] Investigative [543845]
Company
GlaxoSmithKline plc
Canonical SMILES
c1(ccc2c(c1)[C@@H]1[C@H]([C@H](N2)c2ccc(cc2)C)CC=C1)S(=<br />O)(=O)N
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Modulator [543845]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
Chemical carcinogenesis
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 543845(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468).
Ref 543845(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468).

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