Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0YS9E
|
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| Former ID |
DNC007223
|
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| Drug Name |
4-Phenyl-5-piperidin-4-yl-isoxazol-3-ol
|
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| Synonyms |
4-phenyl-5-(4-piperidyl)-3-isoxazolol
|
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| Indication | Discovery agent | Investigative | [527382] | ||
| Target and Pathway | |||||
| Target(s) | Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [528744] | |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Target Info | Inhibitor | [527382] | ||
| Gamma-aminobutyric acid receptor subunit beta-2 | Target Info | Inhibitor | [527382] | ||
| Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [527382] | ||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Iron uptake and transportWP706:SIDS Susceptibility Pathways | |||||
| Iron uptake and transport | |||||
| References | |||||
| Ref 527382 | J Med Chem. 2005 Jan 27;48(2):427-39.Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. | ||||
| Ref 528744 | J Med Chem. 2007 Apr 19;50(8):1988-92. Epub 2007 Mar 22.4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships. | ||||
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