Drug Information

Drug General Information
Drug ID
D0YO8B
Former ID
DIB020311
Drug Name
MCCG
Synonyms
MCCG-I
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538915]
Formula
C7H11NO4
InChI
InChI=1S/C7H11NO4/c1-7(8,6(11)12)4-2-3(4)5(9)10/h3-4H,2,8H2,1H3,(H,9,10)(H,11,12)/t3-,4-,7-/m0/s1
InChIKey
KFACHLANPCGTFI-FVSJBQLASA-N
PubChem Compound ID
5311457
PubChem Substance ID
7980677, 11056521, 15195044, 16118256, 39341131, 52193917, 103215838, 103969305, 114156151, 128372928, 132578366, 135650569, 162247466, 177749652
Target and Pathway
Target(s) Metabotropic glutamate receptor 7 Target Info Antagonist [525945]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 538915(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1439).
Ref 525945Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54.

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