Drug Information

Drug General Information
Drug ID
D0YK5E
Former ID
DNC012496
Drug Name
Oxymorphone semicarbazone hydrochloride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533377]
Formula
C18H23ClN4O4
Canonical SMILES
CN1CCC23C4C(=NNC(=O)N)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl
InChI
1S/C18H22N4O4.ClH/c1-22-7-6-17-13-9-2-3-11(23)14(13)26-15(17)10(20-21-16(19)24)4-5-18(17,25)12(22)8-9;/h2-3,12,15,23,25H,4-8H2,1H3,(H3,19,21,24);1H/b20-10-;/t12?,15-,17?,18+;/m0./s1
InChIKey
QIYGMMZVSGQNFS-XVSNUZMHSA-N
PubChem Compound ID
49860169
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Inhibitor [533377]
Mu-type opioid receptor Target Info Inhibitor [533377]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP69:TCR Signaling Pathway
Opioid Signalling
GPCR downstream signaling
References
Ref 533377J Med Chem. 1986 Jul;29(7):1222-5.Peptides as receptor selectivity modulators of opiate pharmacophores.
Ref 533377J Med Chem. 1986 Jul;29(7):1222-5.Peptides as receptor selectivity modulators of opiate pharmacophores.

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