Drug Information

Drug General Information
Drug ID
D0YC4F
Former ID
DIB005426
Drug Name
K-828-AB
Synonyms
GABA transaminase inhibitor (oral, dementia), Kowa
Indication Dementia [ICD9: 290-294; ICD10:F01-F07] Phase 2 [551074]
Company
Kowa Co Ltd
Target and Pathway
Target(s) 4-aminobutyrate aminotransferase, mitochondrial Target Info Inhibitor [550353]
BioCyc Pathway GABA shunt
Valine degradation
Beta-alanine degradation
4-aminobutyrate degradation
KEGG Pathway Alanine, aspartate and glutamate metabolism
Valine, leucine and isoleucine degradation
beta-Alanine metabolism
Propanoate metabolism
Butanoate metabolism
Metabolic pathways
GABAergic synapse
PANTHER Pathway Aminobutyrate degradation
Pyrimidine Metabolism
Gamma-aminobutyric acid synthesis
PathWhiz Pathway Aspartate Metabolism
Glutamate Metabolism
Beta-Alanine Metabolism
Valine, Leucine and Isoleucine Degradation
Propanoate Metabolism
WikiPathways GABA synthesis, release, reuptake and degradation
Alanine and aspartate metabolism
References
Ref 551074Clinical pipeline report, company report or official report of Kowa Co Ltd.
Ref 550353Phase II clinical trial of K-828-AB for treating behavioral and psychological symptoms of dementia. Kowa Co. Ltd.

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