Drug Information

Drug General Information
Drug ID
D0Y8UF
Former ID
DIB020761
Drug Name
propylpyrazoletriol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539861]
Formula
C24H22N2O3
InChI
InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3
InChIKey
IOTXSIGGFRQYKW-UHFFFAOYSA-N
PubChem Compound ID
6095481
PubChem Substance ID
7473104, 11111273, 11114080, 15376090, 17405137, 24278470, 26732630, 26752190, 40535364, 41615536, 47213243, 47647594, 50104850, 50104851, 53777681, 53788729, 57365432, 57570893, 76227560, 85231075, 85789029, 90341714, 91746532, 92304035, 103357561, 114356391, 121361196, 124749824, 124800652, 124880319, 124880320, 124880321, 128198631, 135334421, 135610564, 135650845, 135697611, 137065926, 162022944, 162250185, 163122507, 163347959, 163564529, 163772841, 179326540, 204361334, 226750948, 241182420, 241375423, 252159975
Target and Pathway
Target(s) Estrogen receptor Target Info Agonist [525879]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancer
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
JAK/STAT
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear Receptors
References
Ref 539861(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2819).
Ref 525879Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology. 2000 Oct;141(10):3534-45.

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