Drug Information

Drug General Information
Drug ID
D0Y4LU
Former ID
DNC000954
Drug Name
MK-912
Drug Type
Small molecular drug
Indication Discovery agent Discontinued in Phase 2 [544718]
Formula
C20H25N3O2
Canonical SMILES
CN1CCC2(CCN3CCC4=C(C3C2)OC5=CC=CC=C45)N(C1=O)C
InChI
1S/C20H25N3O2/c1-21-11-8-20(22(2)19(21)24)9-12-23-10-7-15-14-5-3-4-6-17(14)25-18(15)16(23)13-20/h3-6,16H,7-13H2,1-2H3
InChIKey
JRDUBBHIPPPSLP-UHFFFAOYSA-N
CAS Number
CAS 847049-30-3
PubChem Compound ID
123679
PubChem Substance ID
840955, 10240821, 14875637, 29303897, 47212754, 47275552, 47795043, 50070416, 50071057, 50111138, 57340518, 78168786, 85229926, 90341597, 104419068, 123089203, 124749976, 124880779, 126451840, 131342385, 134222564, 135080044, 179293699
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Antagonist [534977]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 544718Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000716)
Ref 534977Silent alpha(2C)-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries. Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1075-83.

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