Drug Information

Drug General Information
Drug ID
D0Y3TU
Former ID
DNC012079
Drug Name
7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534126]
Formula
C10H9N5
Canonical SMILES
C1=CC2=C(C3=C1NC=C3)C(=NC(=N2)N)N
InChI
1S/C10H9N5/c11-9-8-5-3-4-13-6(5)1-2-7(8)14-10(12)15-9/h1-4,13H,(H4,11,12,14,15)
InChIKey
AMQWKZUAOLLUPP-UHFFFAOYSA-N
PubChem Compound ID
5384532
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [534126]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 534126J Med Chem. 1996 Feb 16;39(4):892-903.High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Ref 534126J Med Chem. 1996 Feb 16;39(4):892-903.High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.

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