Drug Information

Drug General Information
Drug ID
D0Y2GE
Former ID
DNC014420
Drug Name
3-cyano-5-fluoro-N-(pyridin-2-yl)benzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531010]
Formula
C13H8FN3O
Canonical SMILES
C1=CC=NC(=C1)NC(=O)C2=CC(=CC(=C2)C#N)F
InChI
1S/C13H8FN3O/c14-11-6-9(8-15)5-10(7-11)13(18)17-12-3-1-2-4-16-12/h1-7H,(H,16,17,18)
InChIKey
QSQNDNOCUDDTAZ-UHFFFAOYSA-N
PubChem Compound ID
49862277
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [531010]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 531010Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. Epub 2010 Jun 15.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds withCNS exposure in rats.
Ref 531010Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. Epub 2010 Jun 15.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds withCNS exposure in rats.

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