Drug Information

Drug General Information
Drug ID
D0Y2DI
Former ID
DAP001464
Drug Name
Chlorproguanil
Synonyms
Chlorproguanilum; Clorpreguanile; Clorproguanil; Lapudrine; Clorpreguanile [DCIT]; Unspecified HCl of chlorproguanil; Chlorproguanil [INN:BAN]; Chlorproguanilum [INN-Latin]; Clorproguanil [INN-Spanish]; N-(3,4-dichlorophenyl)-N'-(1-methylethyl)imidodicarbonimidic diamide; 1-(3,4-Dichlorophenyl)-5-isopropylbiguanide
Drug Type
Small molecular drug
Indication Malaria [ICD10:B54] Approved [536602]
Formula
C11H15Cl2N5
Canonical SMILES
CC(C)N=C(N)N=C(N)NC1=CC(=C(C=C1)Cl)Cl
InChI
1S/C11H15Cl2N5/c1-6(2)16-10(14)18-11(15)17-7-3-4-8(12)9(13)5-7/h3-6H,1-2H3,(H5,14,15,16,17,18)
InChIKey
ISZNZKHCRKXXAU-UHFFFAOYSA-N
CAS Number
CAS 537-21-3
PubChem Compound ID
9571037
PubChem Substance ID
804511, 10525915, 14897903, 48415767, 50064880, 50563286, 57372909, 104239725, 134338663, 135023251, 135653523, 137102165, 162224584, 162258735, 164838343, 179117193, 198944550, 226428968, 250004001
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [536602]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.

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