Drug Information

Drug General Information
Drug ID
D0Y0ZQ
Former ID
DIB012444
Drug Name
Ecabapide
Synonyms
Ecabamide; Muralis; DQ-2511
Drug Type
Small molecular drug
Indication Peptic ulcer [ICD9: 531-534; ICD10:K25-K27] Discontinued in Preregistration [544686]
Company
Daiichi Seiyaku Co Ltd
Formula
C20H25N3O4
Canonical SMILES
C(=O)(c1cc(NCC(=O)NCCc2cc(c(cc2)OC)OC)ccc1)NC
CAS Number
CAS 104775-36-2
PubChem Compound ID
65885
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Modulator [534260]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 544686Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000582)
Ref 534260Identification of major biliary and urinary metabolites of ecabapide in rats. Xenobiotica. 1996 Sep;26(9):983-94.

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