Drug Information

Drug General Information
Drug ID
D0XM4G
Former ID
DIB010823
Drug Name
Bindarit
Synonyms
Bindarit, Angelini Pharmaceuticals; CCL2 inhibitor (inflammatory disorders/kidney disease), Angelini Pharmaceuticals; MCP-1 inhibitor (inflammatory disorder/kidney disease), Angelini Pharmaceuticals
Drug Type
Small molecular drug
Indication Nephritis [ICD10:N00-N19, N25-N29] Phase 3 [531744]
Company
Angelini Pharmaceuticals SpA
Formula
C19H20N2O3
Canonical SMILES
n1(nc(c2c1cccc2)COC(C(=O)O)(C)C)Cc1ccccc1
PubChem Compound ID
71354
Target and Pathway
Target(s) C-C motif chemokine 2 Target Info Inhibitor [531744]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NOD-like receptor signaling pathway
TNF signaling pathway
Chagas disease (American trypanosomiasis)
Malaria
Influenza A
Herpes simplex infection
Rheumatoid arthritis
NetPath Pathway IL9 Signaling Pathway
IL5 Signaling Pathway
IL1 Signaling Pathway
TSH Signaling Pathway
TWEAK Signaling Pathway
IL4 Signaling Pathway
TNFalpha Signaling Pathway
TSLP Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database GMCSF-mediated signaling events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
AP-1 transcription factor network
IL23-mediated signaling events
Reactome Chemokine receptors bind chemokines
ATF4 activates genes
WikiPathways IL1 and megakaryotyces in obesity
Activation of Genes by ATF4
Spinal Cord Injury
Oncostatin M Signaling Pathway
TNF alpha Signaling Pathway
TWEAK Signaling Pathway
IL-1 signaling pathway
GPCR ligand binding
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 531744Bindarit: an anti-inflammatory small molecule that modulates the NF?B pathway. Cell Cycle. 2012 Jan 1;11(1):159-69.
Ref 531744Bindarit: an anti-inflammatory small molecule that modulates the NF?B pathway. Cell Cycle. 2012 Jan 1;11(1):159-69.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.