Drug Information

Drug General Information
Drug ID
D0X9RM
Former ID
DNC011966
Drug Name
2-Thiophen-2-ylmethyl-1,2-dihydro-indazol-3-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529474]
Formula
C12H10N2OS
Canonical SMILES
C1=CC=C2C(=C1)C(=O)N(N2)CC3=CC=CS3
InChI
1S/C12H10N2OS/c15-12-10-5-1-2-6-11(10)13-14(12)8-9-4-3-7-16-9/h1-7,13H,8H2
InChIKey
JGPURYLHMLRGGI-UHFFFAOYSA-N
PubChem Compound ID
14898713
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [529474]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 529474J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.
Ref 529474J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.

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