Drug Information

Drug General Information
Drug ID
D0X9PI
Former ID
DIB019565
Drug Name
compound 68
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527816], [532825]
Formula
C17H11BrFN5OS
InChI
InChI=1S/C17H11BrFN5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(18)6-9(10)19/h2-7,20H,1H3,(H,21,22,23)
InChIKey
ZBELDPMWYXDLNY-UHFFFAOYSA-N
PubChem Compound ID
71529752
PubChem Substance ID
163523579, 174506683, 175446673, 239706996, 249565845
Target and Pathway
Target(s) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Target Info Inhibitor [532825]
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B Target Info Inhibitor [532825]
References
Ref 527816Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Neurobiol Dis. 2005 Nov;20(2):392-400.
Ref 532825Tricyclic Pyrimidines As Inhibitors of DYRK1A/DYRK1B As Potential Treatment for Down's Syndrome or Alzheimer's Disease. ACS Med Chem Lett. 2013 Apr 26;4(6):502-3.
Ref 532825Tricyclic Pyrimidines As Inhibitors of DYRK1A/DYRK1B As Potential Treatment for Down's Syndrome or Alzheimer's Disease. ACS Med Chem Lett. 2013 Apr 26;4(6):502-3.

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