Drug Information

Drug General Information
Drug ID
D0X0PW
Former ID
DIB010802
Drug Name
Revamilast
Synonyms
GRC-4039; PDE 4 inhibitor (inflammation), Glenmark; Phosphodiesterase 4 inhibitor (inflammation), Glenmark; Revamilast (inflammation), Glenmark
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 2 [523630]
Company
Glenmark Pharmaceuticals Ltd
Formula
C18H9Cl2F2N3O4
Canonical SMILES
c1(ccc(c2c1oc1c2cncc1)C(=O)Nc1c(c[n+](cc1Cl)[O-])Cl)OC(<br />F)F
CAS Number
CAS 893555-90-3
PubChem Compound ID
11546664
Target and Pathway
Target(s) Type IV phosphodiesterase Target Info Inhibitor [550161]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [550161]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [550161]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
TSH signaling pathwayWP35:G Protein Signaling Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
References
Ref 523630ClinicalTrials.gov (NCT01436890) A Clinical Trial to Study the Effects of Revamilast in Patients With Chronic Persistent Asthma. U.S. National Institutes of Health.
Ref 550161WO patent application no. 2012,1109,46, Pharmaceutical composition comprising the pde4 enzyme inhibitor revamilast and a disease modifying agent, preferably methotrexate .

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