Drug Information

Drug General Information
Drug ID
D0WV5J
Former ID
DIB020185
Drug Name
L-888,291
Synonyms
L-883,595
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539181]
Formula
C19H15ClFNO2S
InChI
InChI=1S/C19H15ClFNO2S/c20-12-1-4-14(5-2-12)25-19-15-6-3-13(21)10-16(15)22-8-7-11(18(19)22)9-17(23)24/h1-6,10-11H,7-9H2,(H,23,24)
InChIKey
GSBAVONRPNJJOH-UHFFFAOYSA-N
PubChem Compound ID
44450494
PubChem Substance ID
90074170, 103567031, 135650503, 162473546, 163417258, 163850315, 189053657, 196378972, 245775372, 252461465
Target and Pathway
Target(s) Prostaglandin D2 receptor Target Info Agonist [527465]
Putative G-protein coupled receptor 44 Target Info Agonist [527465]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 539181(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1880).
Ref 527465Identification of a potent and selective synthetic agonist at the CRTH2 receptor. Mol Pharmacol. 2005 Jun;67(6):1834-9. Epub 2005 Mar 8.

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