Drug Information

Drug General Information
Drug ID
D0WU9R
Former ID
DNC004182
Drug Name
L-741742
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540264]
Formula
C23H25ClN2O
InChI
InChI=1S/C23H25ClN2O/c1-17-22(25-27-23(17)20-7-9-21(24)10-8-20)19-12-15-26(16-13-19)14-11-18-5-3-2-4-6-18/h2-10,19H,11-16H2,1H3
InChIKey
QDMAKDIDFJTXEL-UHFFFAOYSA-N
PubChem Compound ID
133008
PubChem Substance ID
4724103, 7979698, 10243266, 11113849, 14877954, 26752022, 29311020, 47734100, 48256818, 57344347, 75175873, 85223051, 85788362, 103247294, 103947646, 104378768, 129007064, 134341387, 135088074, 142936469, 164339487, 178100339, 227605153
Target and Pathway
Target(s) Sodium channel Target Info Inhibitor [525540]
D(3) dopamine receptor Target Info Inhibitor [534132]
Voltage-gated sodium channel subunit alpha Nav1.3 Target Info Inhibitor [525540]
D(4) dopamine receptor Target Info Inhibitor [534132]
KEGG Pathway Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Interaction between L1 and AnkyrinsR-HSA-390651:Dopamine receptors
G alpha (i) signalling eventsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
GPCRs, Other
References
Ref 540264(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3302).
Ref 525540J Med Chem. 1999 Jul 15;42(14):2706-15.1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.
Ref 534132J Med Chem. 1996 May 10;39(10):1943-5.5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.

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