Drug Information

Drug General Information
Drug ID
D0WH9U
Former ID
DIB008486
Drug Name
FK-070
Drug Type
Small molecular drug
Indication Angina pectoris [ICD9: 413; ICD10:I20] Phase 2 [534202]
Formula
C22H27Cl2N3O4S
Canonical SMILES
C1C(CN(C1C=CCCCC(=O)O)CC2=CN=CC=C2)NS(=O)(=O)C3=CC=C(C=<br />C3)Cl.Cl
InChI
1S/C22H26ClN3O4S.ClH/c23-18-8-10-21(11-9-18)31(29,30)25-19-13-20(6-2-1-3-7-22(27)28)26(16-19)15-17-5-4-12-24-14-17;/h2,4-6,8-12,14,19-20,25H,1,3,7,13,15-16H2,(H,27,28);1H/b6-2-;/t19-,20-;/m1./s1
InChIKey
JGCFJVFIRFTRKJ-YOLZMAEBSA-N
CAS Number
CAS 130047-27-7
PubChem Compound ID
6442424
PubChem Substance ID
11968934, 12014726, 14762122, 14933303, 43035010, 57369341, 79702535, 114565854, 135158508, 224967530, 234146275
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Modulator [534202]
Thromboxane-A synthase Target Info Modulator [534202]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activationhsa00590:Arachidonic acid metabolism
Metabolic pathways
Platelet activation
PathWhiz Pathway Arachidonic Acid Metabolism
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
References
Ref 534202Pharmacokinetic and pharmacodynamic properties of FK070 (KDI-792), a novel thromboxane receptor antagonist/thromboxane synthetase inhibitor, after single and multiple oral administrations to healthy volunteers. J Pharm Pharmacol. 1996 Apr;48(4):380-5.
Ref 534202Pharmacokinetic and pharmacodynamic properties of FK070 (KDI-792), a novel thromboxane receptor antagonist/thromboxane synthetase inhibitor, after single and multiple oral administrations to healthy volunteers. J Pharm Pharmacol. 1996 Apr;48(4):380-5.

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