Drug Information

Drug General Information
Drug ID
D0WE4C
Former ID
DIB020122
Drug Name
K185
Synonyms
K-185; K 185
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538836]
Formula
C24H28N2O2
InChI
InChI=1S/C24H28N2O2/c1-3-7-23(27)25-14-13-20-21-16-18(28-2)11-12-22(21)26-15-6-9-17-8-4-5-10-19(17)24(20)26/h4-5,8,10-12,16H,3,6-7,9,13-15H2,1-2H3,(H,25,27)
InChIKey
SPIFQXPRSJKRAO-UHFFFAOYSA-N
PubChem Compound ID
5311198
PubChem Substance ID
7979673, 11056331, 11111349, 15473742, 17405257, 24278505, 39340907, 47720609, 50106509, 50106510, 53777802, 57359385, 74465607, 85209124, 85231100, 90341806, 92304305, 103169525, 103985410, 114155523, 121361657, 124749923, 124880491, 135289167, 135650451, 162250177, 163135323, 163564650, 179235834
Target and Pathway
Target(s) Melatonin receptor Target Info Antagonist [525729]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538836(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1359).
Ref 525729Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles.J Med Chem. 2000 Mar 23;43(6):1050-61.

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