Drug Information

Drug General Information
Drug ID
D0W9VN
Former ID
DIB021187
Drug Name
VU0364770
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541403]
Formula
C12H9ClN2O
InChI
InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)
InChIKey
SUYUTNCKIOLMAJ-UHFFFAOYSA-N
PubChem Compound ID
836002
PubChem Substance ID
1075412, 7068684, 8240697, 45826308, 50781779, 81083915, 85240655, 89676687, 103692716, 104135294, 107567746, 110019984, 119048943, 162009803, 162619066, 163563935, 178102855, 196377575, 228633058, 248986748, 249548948, 252158087, 252472568
Target and Pathway
Target(s) Metabotropic glutamate receptor 4 Target Info Modulator (allosteric modulator) [531700]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transduction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 541403(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6234).
Ref 531700The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J Pharmacol Exp Ther. 2012 Feb;340(2):404-21.

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